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Updated: Jun 9, 2026
06:46
Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
Published on: December 14, 2020
Summary
Intravenous metoclopramide increases lower esophageal sphincter pressure and reduces reflux episodes in patients with gastroesophageal reflux disease. This medication also enhances esophageal acid clearance, offering a potential therapeutic benefit.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Gastroesophageal reflux disease (GERD) is a common condition characterized by the abnormal reflux of stomach contents into the esophagus.
- The lower esophageal sphincter (LES) plays a crucial role in preventing reflux; impaired LES pressure is a key factor in GERD pathogenesis.
Purpose of the Study:
- To investigate the effect of intravenous metoclopramide on gastroesophageal sphincter pressure in patients with GERD.
- To assess the impact of metoclopramide on esophageal clearance and the frequency of reflux episodes.
Main Methods:
- Thirty patients with GERD received intravenous metoclopramide, with LES pressure monitored.
- Eighteen patients with GERD were assessed for reflux episode frequency and esophageal acid clearance after metoclopramide administration.
- Dose-response relationship and effects of atropine were evaluated.
Main Results:
- Intravenous metoclopramide significantly increased gastroesophageal sphincter pressure in a dose-dependent manner.
- The pressure increase reached a plateau proportional to the resting sphincter tone and was reversible by atropine.
- Metoclopramide reduced the frequency of reflux episodes and accelerated esophageal acid clearance.
Conclusions:
- Metoclopramide enhances lower esophageal sphincter pressure and improves esophageal acid clearance in GERD patients.
- The drug's prokinetic and anti-reflux effects suggest its utility in managing gastroesophageal reflux disease.
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