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[Pulmonary mucormycoses (author's transl)]
Abstract:
Mucormycoses are rare, acute infections, most often fatal, occurring usually in a host with decreased immunity. The agents are ubiquitous fungi belonging to the Mucoraceae family, an ordinary saprophyte becoming pathogenous in patients with a severe disease (malignant hemopathy, diabetes) or treated by immunosuppressive drugs. Pulmonary localizations remained exceptional (128 cases found in the literature). The observations reported draws its originality from: -- the etiological circumstances: an aged patient with no hemopathy or diabetes, without immunosuppressive treatment but undergoing a prolonged antibiotic therapy; -- the clinical signs: discovery on X-ray of excavated infiltrates in a background of a severe infection with a very poor physical condition; -- the diagnosis criteria with the demonstration of the responsible mucor in the sputum, the endobronchial aspiration and transparietal puncture; -- the great efficiency of Amphotericin B at rather small doses. A review of the literature underlines the exceptional character of the cure.
Insights
This study details a rare, fatal pulmonary mucormycosis case in an elderly patient. Prompt diagnosis and Amphotericin B treatment led to an exceptional cure, highlighting effective management strategies for invasive fungal infections.
Area of Science:
- Mycology
- Infectious Diseases
- Pulmonology
Background:
- Mucormycoses are rare, life-threatening fungal infections, typically affecting immunocompromised individuals.
- Pulmonary mucormycosis is exceptionally rare, with few documented cases in medical literature.
- Risk factors usually include severe diseases like diabetes or hematologic malignancies, and immunosuppressive therapy.