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Published on: March 14, 2017
Neuromuscular disease in secondary hyperparathyroidism
Annals of Internal Medicine
|April 1, 1975
Summary
Osteomalacia patients experience treatable neuromuscular issues, primarily weakness and fatigue, similar to primary hyperparathyroidism. This neuropathic condition improves with osteomalacia treatment.
Area of Science:
- Neurology
- Endocrinology
- Bone Metabolism
Background:
- Osteomalacia and secondary hyperparathyroidism can cause neuromuscular dysfunction.
- Patients often present with proximal muscle weakness, atrophy, and fatigability.
- Neurological symptoms can mimic those seen in primary hyperparathyroidism.
Purpose of the Study:
- To evaluate neuromuscular function in patients with osteomalacia or secondary hyperparathyroidism.
- To determine the nature of the neuromuscular disease in these patients.
- To assess the impact of treating osteomalacia on neuromuscular function.
Main Methods:
- Electromyography and muscle biopsy studies were performed on six patients.
- Bone biopsy was used to confirm osteomalacia.
- Immunoreactive parathyroid hormone levels were measured.
Main Results:
- All patients exhibited evidence of neuropathic muscle disease.
- Muscle biopsies showed no definitive myopathic features.
- Treatment of osteomalacia led to improved muscle strength.
Conclusions:
- Osteomalacia is associated with a treatable, neuropathic neuromuscular disease.
- The neuromuscular abnormalities resemble those found in primary hyperparathyroidism.
- Neuromuscular dysfunction in osteomalacia is primarily neuropathic, not myopathic.
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