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Related Experiment Videos

Plasma beta-endorphin immunoreactivity in schizophrenia.

M Ross, P A Berger, A Goldstein

    Science (New York, N.Y.)
    |September 14, 1979
    PubMed
    Summary

    Plasma beta-endorphin levels in schizophrenic patients were similar to healthy individuals. No beta-endorphin was detected in hemodialysis fluid, contradicting previous findings in schizophrenia research.

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    NeuroImage·2019

    Area of Science:

    • Neuroscience
    • Biochemistry
    • Psychiatry

    Background:

    • Opioid peptides, such as beta-endorphin, have been investigated for their potential role in psychiatric disorders.
    • Previous studies suggested elevated levels of [Leu5]-beta-endorphin in the hemodialysates of schizophrenic patients.

    Purpose of the Study:

    • To investigate plasma beta-endorphin-like immunoreactivity in schizophrenic patients.
    • To examine the presence of beta-endorphin in hemodialysates of schizophrenic and nonpsychotic renal patients.

    Main Methods:

    • Measurement of plasma beta-endorphin-like immunoreactivity using a sensitive assay.
    • Analysis of hemodialysates from patients undergoing first-time hemodialysis.

    Main Results:

    • Plasma beta-endorphin-like immunoreactivity did not significantly differ between 98 schizophrenic patients and 42 normal subjects.
    • No detectable beta-endorphin immunoreactivity was found in the hemodialysates of eight nonpsychotic renal patients and nine schizophrenic patients.

    Conclusions:

    • The findings do not support previous reports of high [Leu5]-beta-endorphin concentrations in schizophrenic hemodialysates.
    • This study suggests that plasma beta-endorphin levels are not significantly altered in schizophrenia and are not present in hemodialysates.

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