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Antibacterial activity of amniotic fluid.
Summary
Antibacterial activity in amniotic fluid was lower in late pregnancy, linked to reduced zinc levels. This may explain increased rates of amniotic fluid infection during this period.
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases
- Nutritional Biochemistry
Background:
- Amniotic fluid infection (AFI) is a significant complication in late pregnancy.
- The antibacterial properties of amniotic fluid are crucial for preventing intrauterine infections.
Purpose of the Study:
- To investigate the antibacterial activity of amniotic fluid in the third trimester of pregnancy.
- To assess the relationship between amniotic fluid zinc levels and antibacterial function.
- To explore potential explanations for the high incidence of AFI.
Main Methods:
- Collection of amniotic fluid samples from mothers in the last month of pregnancy in Cape Town.
- Assay of antibacterial activity against Escherichia coli.
- Measurement of zinc concentrations in amniotic fluid.
Main Results:
- Reduced antibacterial activity of amniotic fluid was observed in the study sample.
- Lower concentrations of zinc were found in amniotic fluid samples.
- A correlation between reduced zinc and diminished antibacterial capacity is suggested.
Conclusions:
- Decreased amniotic fluid zinc levels may impair its antibacterial activity in late pregnancy.
- This zinc deficiency could contribute to the high incidence of amniotic fluid infection.
- Findings highlight the importance of zinc for maintaining a sterile intrauterine environment.