Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serum dopamine-beta-hydroxylase activity: sibling-sibling correlation.

R M Weinshilboum, F A Raymond, L R Elveback

    Science (New York, N.Y.)
    |September 7, 1973
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    New insights into the pharmacogenomics of antidepressant response from the GENDEP and STAR*D studies: rare variant analysis and high-density imputation.

    The pharmacogenomics journal·2017
    Same author

    A prospective genome-wide study of prostate cancer metastases reveals association of wnt pathway activation and increased cell cycle proliferation with primary resistance to abiraterone acetate-prednisone.

    Annals of oncology : official journal of the European Society for Medical Oncology·2017
    Same author

    Genetic Breast Cancer Susceptibility Variants and Prognosis in the Prospectively Randomized SUCCESS A Study.

    Geburtshilfe und Frauenheilkunde·2017
    Same author

    Electronic Medical Record-Integrated Pharmacogenomics and Related Clinical Decision Support Concepts.

    Clinical pharmacology and therapeutics·2017
    Same author

    The Pharmacogenomics Research Network Translational Pharmacogenetics Program: Outcomes and Metrics of Pharmacogenetic Implementations Across Diverse Healthcare Systems.

    Clinical pharmacology and therapeutics·2017
    Same author

    Are patients willing to incur out-of-pocket costs for pharmacogenomic testing?

    The pharmacogenomics journal·2016

    Serum dopamine-beta-hydroxylase (DBH) activity, released from the adrenal medulla and sympathetic nerves, showed significant sibling correlations. Enzyme activity distributions in children and adults suggest two distinct populations, indicating genetic influences on DBH levels.

    Area of Science:

    • Biochemistry
    • Human Physiology
    • Genetics

    Background:

    • Dopamine-beta-hydroxylase (DBH) is an enzyme crucial for catecholamine synthesis.
    • DBH activity is released into circulation from the adrenal medulla and sympathetic nerve endings.
    • Understanding DBH activity is important for studying neuroendocrine and cardiovascular functions.

    Purpose of the Study:

    • To measure serum DBH activity in a large cohort of normal children and adults.
    • To investigate the familial aggregation of serum DBH activity by examining sibling correlations.
    • To explore the population distribution of serum DBH activity.

    Main Methods:

    • Serum samples were collected from 317 normal children and 227 normal adults.
    • Enzyme activity assays were performed to quantify DBH levels.

    Related Experiment Videos

  • Statistical analyses were conducted to assess sibling correlations and population distributions.

    • Main Results:

    • Significant positive correlations were observed between sibling pairs for serum DBH activity (n=94 pairs).
    • Frequency distribution analysis revealed distinct patterns suggesting two separate populations based on enzyme activity levels in both children and adults.
    • These findings indicate a potential genetic component influencing DBH levels.

    Conclusions:

    • Serum DBH activity exhibits significant familial aggregation, suggesting a genetic basis.
    • The presence of two distinct populations implies a dimorphic distribution of DBH activity.
    • Further research into the genetic and environmental factors influencing DBH activity is warranted.