Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A new material concept for the red cell membrane.

E A Evans

    Biophysical Journal
    |September 1, 1973
    PubMed
    Summary
    This summary is machine-generated.

    The red blood cell membrane acts as a 2D incompressible material, explaining its large deformations and spherical shape. This model provides insights into cell mechanics and transformations.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Clinical experience across the fetal-fraction spectrum of a non-invasive prenatal screening approach with low test-failure rate.

    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2019
    Same author

    High-voltage SPM oxidation of ZrN: materials for multiscale applications.

    Nanotechnology·2011
    Same author

    Enzyme systems operating within the malarial parasite.

    Federation proceedings·2010
    Same author

    The biochemistry of the malaria parasite; the in vitro effects of x-rays upon Plasmodium gallinaceum.

    The Journal of infectious diseases·2010
    Same author

    The biochemistry of the malaria parasite; mechanism of pyruvate oxidation in the malaria parasite.

    The Journal of biological chemistry·2010
    Same author

    The biochemistry of the malaria parasite; studies on the nitrogen metabolism of the malaria parasite.

    The Journal of biological chemistry·2010

    Area of Science:

    • Biophysics
    • Cell Biology
    • Materials Science

    Background:

    • Red blood cell membranes exhibit complex mechanical properties, including large deformability and shape transitions.
    • Existing models do not fully capture the interplay between membrane structure and its mechanical behavior during deformations.

    Purpose of the Study:

    • To propose a new mechanical model for the red blood cell membrane as a two-dimensional incompressible material.
    • To develop a general stress-strain law for finite deformations of the red cell membrane.
    • To explain the observed mechanical properties, such as large deformations and rigidity in different states.

    Main Methods:

    • Development of a general stress-strain relationship for a two-dimensional incompressible material.
    • Linearization of the stress-strain law to compare with existing material models (e.g., Mooney material).

    Related Experiment Videos

  • Application of the model to analyze the discocyte-to-osmotic spherocyte transformation in single red blood cells.

    • Main Results:

    • The red cell membrane is modeled as a two-dimensional incompressible material with a stress-strain law applicable to finite deformations.
    • The linear form of the law is analogous to a two-dimensional Mooney material, suggesting a cross-linked protein network and a liquid lipid bilayer.
    • The model successfully demonstrates how such a membrane can form a sphere at constant area and explains shape transitions.

    Conclusions:

    • The proposed two-dimensional incompressible material model accurately describes the red blood cell membrane's mechanical behavior.
    • The model elucidates the structural basis for the membrane's large deformability and rigidity.
    • This framework provides a mechanistic understanding of red blood cell shape transformations, crucial for understanding cell function and pathology.