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Coma associated with vincristine therapy.

J A Whittaker, D H Parry, C Bunch

    British Medical Journal
    |November 10, 1973
    PubMed
    Summary
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    Vincristine therapy can cause temporary coma, sometimes linked to the syndrome of inappropriate antidiuretic hormone secretion. All patients in this study fully recovered from these neurological effects.

    Area of Science:

    • Oncology
    • Neurology
    • Endocrinology

    Background:

    • Vincristine is a common chemotherapy agent.
    • Neurological side effects of vincristine are known.
    • Coma is a rare but serious adverse event.

    Purpose of the Study:

    • To report three cases of coma following vincristine therapy.
    • To investigate potential mechanisms, including the syndrome of inappropriate antidiuretic hormone secretion (SIADH).

    Main Methods:

    • Case series review.
    • Clinical observation and patient monitoring.

    Main Results:

    • Three patients developed coma after vincristine administration.
    • One patient presented with hyponatremia and SIADH.

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  • All neurological effects were transient, with complete recovery in all cases.

    • Conclusions:

    • Vincristine-induced coma is a reversible neurological complication.
    • SIADH may be implicated in some cases of vincristine-induced coma.
    • Close monitoring and supportive care are essential for patients receiving vincristine.