Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Sinus node disease affecting both parents and both children.

A F Mackintosh, D A Chamberlain

European Journal of Cardiology

|August 1, 1979

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

trans-2-Nonenal insect repellent, insecticide, and flavor compound in carrot roots, cell suspensions, and "hairy" root cultures.

Journal of chemical ecology·2013

Same author

pEmu: an improved promoter for gene expression in cereal cells.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2013

Same author

Coronary care: home or hospital.

Proceedings of the Royal Society of Medicine·2010

Same author

Bilateral Upper Thoracic Sympathectomy in Angina Pectoris: Results in 52 Cases.

British medical journal·2010

Same author

A national scheme for public access defibrillation in England and Wales: early results.

Resuscitation·2008

Same author

Sympathetic nerve hyperactivity of essential hypertension is lower in postmenopausal women than men.

Journal of human hypertension·2008

Same journal

Left ventricular aneurysm: pre- and postoperative haemodynamic studies at rest and during exercise.

European journal of cardiology·1981

Same journal

Changes of left ventricular contractility in alternating left bundle branch block.

European journal of cardiology·1981

Same journal

Jugular pulse and flow velocity anomalies: a diagnostic clue to an obstructive tricuspid prosthetic dysfunction.

European journal of cardiology·1981

Same journal

Electrocardiogram in primary pulmonary hypertension.

European journal of cardiology·1981

Same journal

Free ball thrombus of the left atrium.

European journal of cardiology·1981

Same journal

Echocardiographic identification and analysis of function of the St. Jude medical heart valve prosthesis.

European journal of cardiology·1981

See all related articles

A family experienced early-onset conducting system disease, including sinus node dysfunction, before age 40. This suggests a potential genetic link to cardiac conduction disorders and childhood polyneuritis.

Area of Science:

Cardiology
Genetics
Neurology

Background:

Conducting system disease can manifest as arrhythmias and heart block.
Sinus node dysfunction is a common cause of bradycardia.
Early-onset conditions may indicate underlying genetic predispositions.

Observation:

A four-generation family presented with early-onset conducting system disease.
All affected members showed signs of sinus node dysfunction.
Two members experienced childhood polyneuritis.

Findings:

The family exhibited a high prevalence of conducting system disease before age 40.
Sinus node dysfunction was a consistent finding across affected individuals.
The co-occurrence of polyneuritis in father and son warrants further investigation.

Related Experiment Videos

Implications:

This family's condition suggests a potential hereditary component to conducting system disease.
Early-onset sinus node dysfunction may be an indicator for genetic screening.
Further research is needed to identify the specific genetic mutation responsible.