[Protective action of estrogen-progestin preparations in reproductive function disorder from subtoxic doses of...

The action of subtoxic doses of armine and nibufin administered alone and combined with steroid drugs on the rat reproductive function and uterine tissue RNA content was studied experimentally. The subtoxic doses of the drugs increased sharply the luteinizing hormone releasing factor content in the hypothalamus, as well as the synthesis and excretion of luteinizing and follicle-stimulating hormones and RNA content in the uterine tissue. Estrogen-progestin drugs, particularly infecundin, exerted a protective action in armine- and nibufin-produced abnormalities of the reproductive function.