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Single fibre electromyography in central core disease.
Journal of Neurology, Neurosurgery, and Psychiatry
|July 1, 1979
Summary
Central core disease patients show higher motor unit fiber density in extensor digitorum communis muscles. This finding in single fiber electromyography suggests increased terminal innervation, consistent with prior central core disease research.
Area of Science:
- Neurology
- Muscle Physiology
Background:
- Central core disease is a congenital myopathy.
- Previous research suggests altered innervation in central core disease.
Purpose of the Study:
- To investigate motor unit properties in patients with central core disease.
- To assess muscle fiber density using single fiber electromyography.
Main Methods:
- Single fiber electromyography was performed on the extensor digitorum communis muscle.
- Electromyography data was analyzed in five patients with central core disease and compared to healthy controls.
Main Results:
- Patients with central core disease exhibited a higher average number of muscle fiber action potentials per motor unit.
- This indicates an increased motor unit fiber density in the affected muscle.
Conclusions:
- The findings support the hypothesis of increased terminal innervation ratio in central core disease.
- Single fiber electromyography is a valuable tool for characterizing neuromuscular alterations in central core disease.