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Physical characterization of solid iopanoic acid forms.

W C Stagner, J K Guillory

    Journal of Pharmaceutical Sciences
    |August 1, 1979
    PubMed
    Summary
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    The amorphous and Form II solid states of iopanoic acid significantly enhance dissolution rates compared to the commercial form. The amorphous form

    Area of Science:

    • Pharmaceutical Sciences
    • Solid-State Chemistry
    • Materials Science

    Background:

    • Iopanoic acid is a key pharmaceutical compound.
    • Understanding its solid-state properties is crucial for drug formulation.
    • Previous characterization may not have identified all solid forms.

    Purpose of the Study:

    • To characterize the solid forms of iopanoic acid.
    • To investigate the impact of different solid forms on dissolution properties.
    • To compare the stability of various iopanoic acid forms.

    Main Methods:

    • X-ray diffraction for structural analysis.
    • Differential scanning calorimetry for thermal properties.
    • Scanning electron microscopy and thermal microscopy for morphology.

    Related Experiment Videos

  • Infrared spectroscopy for chemical identification.
  • Dissolution studies to assess drug release.

    • Main Results:

    • Identified three solid forms: two crystalline and one amorphous.
    • The amorphous form, previously misidentified, showed a 10x greater intrinsic dissolution rate than Form I.
    • Form II exhibited a 1.5x greater intrinsic dissolution rate than Form I.
    • Solubilities correlated with intrinsic dissolution rates.
    • Amorphous form converted rapidly to Form I in aqueous solutions; Form II was more stable.

    Conclusions:

    • The amorphous and Form II solid forms of iopanoic acid offer improved dissolution profiles.
    • Solid-state characterization is vital for optimizing pharmaceutical formulations.
    • Stability differences between forms impact their practical application.