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Related Experiment Videos

Reye's syndrome in nonpediatric age groups.

R R Varma, D R Riedel, R A Komorowski

    JAMA
    |September 28, 1979
    PubMed
    Summary

    Reye's syndrome, typically a childhood illness, can affect adults. This study highlights four adult cases, emphasizing its potential misdiagnosis in adult encephalopathy.

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    Area of Science:

    • Neurology
    • Pediatrics
    • Internal Medicine

    Background:

    • Reye's syndrome is a rare but serious condition primarily affecting children, characterized by encephalopathy and fatty liver.
    • It is often preceded by a viral illness and is associated with specific biochemical abnormalities.

    Observation:

    • This study presents four cases of Reye's syndrome in young adults (aged 16-23) initially managed by internists.
    • Clinical presentation included viral prodrome, vomiting, and encephalopathy without focal neurological signs or jaundice.
    • Cerebrospinal fluid (CSF) examination showed normal findings except for increased opening pressure, alongside abnormal liver function tests and elevated blood ammonia.

    Findings:

    • Reye's syndrome was linked to influenza B virus in three patients and Varicella in one.
    • All patients presented with encephalopathy and fatty liver, with elevated ammonia levels and abnormal liver function tests.
    • Three out of the four adult patients survived the illness.

    Implications:

    • Reye's syndrome should be considered in the differential diagnosis of unexplained encephalopathy in adults.
    • Early recognition by internists, emergency physicians, and psychiatrists is crucial for timely diagnosis and management.
    • This study expands the known age spectrum for Reye's syndrome, underscoring the need for broader clinical awareness.

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