[The resorption of cotrimoxazol from preparations produced by different manufacturies (author's transl)]

In a pharmacokinetic study with healthy test persons we compared the forte-tablet form of cotrimoxazol produced by 4 different manufacturers. We were able to show that 3 of the tested products (2 well known standard products I and II as well as a new comparative product) achieved nearly equal high serum concentrations of sulfamethoxazole and trimethoprim. The serum concentrations of a fourth product, a generic product, were lower for sulfamethoxazole and trimethoprim. As the difference is of no statistical significance and the serum concentrations of the last product are within the therapeutic range this product is also qualified for therapeutic use. When the dose is given after a standard breakfast the serum values of sulfamethoxazole were slightly higher than if given on an empty stomach. However, the serum values of trimethoprim given on an empty stomach were higher.