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Feedback control dynamics for glucose controlled insulin infusion system.

A H Clemens

    Medical Progress Through Technology
    |June 15, 1979
    PubMed
    Summary
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    The BIOSTATOR, a Glucose Controlled Insulin Infusion System (GCIIS), enables detailed investigation of carbohydrate metabolism and diabetes-related regulatory issues. This advanced system provides real-time glucose monitoring and precise insulin/dextrose delivery for diabetes research.

    Area of Science:

    • Biomedical Engineering
    • Endocrinology
    • Medical Devices

    Background:

    • Diabetes mellitus involves complex carbohydrate metabolism and regulatory deficiencies.
    • Accurate, real-time glucose monitoring is crucial for understanding metabolic control.
    • Existing methods may lack the speed and precision required for dynamic physiological studies.

    Purpose of the Study:

    • To introduce the Glucose Controlled Insulin Infusion System (GCIIS), trademarked BIOSTATOR.
    • To present the BIOSTATOR as a tool for investigating carbohydrate metabolism and diabetes regulatory mechanisms.
    • To detail the system's components and operational capabilities for physiological research.

    Main Methods:

    • Development of a Glucose Controlled Insulin Infusion System (GCIIS) with real-time glucose analysis.

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  • Integration of a computer controller for calculating and managing insulin/dextrose infusion rates.
  • Utilization of a rapid electrochemical glucose sensor and a multichannel peristaltic pump system.

    • Main Results:

    • The BIOSTATOR features a rapid on-line glucose analyzer with a response time under 90 seconds.
    • The system allows for precise, computer-controlled insulin and dextrose infusions based on real-time glucose data.
    • A silent printer provides minute-by-minute data logging of glucose levels and infusion rates.

    Conclusions:

    • The BIOSTATOR GCIIS offers a significant advancement for studying the physiological control of carbohydrate metabolism.
    • Its real-time analysis and controlled infusion capabilities are valuable for diabetes research.
    • The system facilitates dynamic control strategies, moving beyond predicted glucose values.