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Updated: May 4, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

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Superficial and juxtamedullary nephron function during saline loading in the dog.

F J Bruns, E A Alexander, A L Riley

    The Journal of Clinical Investigation
    |April 1, 1974
    PubMed
    Summary

    Saline expansion in dogs shifts kidney filtration towards superficial nephrons, increasing superficial (SNGFR) and decreasing juxtamedullary (JMGFR) rates. This indicates a potential impact on sodium excretion by juxtamedullary nephrons.

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