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Interaction between natural selection for heterozygotes and directional selection.

M W Verghese

    Genetics
    |January 1, 1974
    PubMed
    Summary
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    A selection plateau may occur when directional selection is opposed by natural selection. The response depends on initial selection and natural selection intensity, especially in small populations where gene frequencies are critical for allele fixation.

    Area of Science:

    • Population Genetics
    • Quantitative Genetics
    • Evolutionary Biology

    Background:

    • Directional selection can lead to fixation of alleles.
    • Natural selection can oppose directional selection, particularly when heterozygotes have a fitness advantage (overdominance).
    • This opposition can result in a selection plateau, where genetic variation is maintained despite selection pressure.

    Purpose of the Study:

    • To investigate the conditions under which a selection plateau is reached in the presence of opposing selection pressures.
    • To determine the factors influencing the magnitude of response once a plateau is reached.
    • To assess the role of population size and initial gene frequencies in allele fixation probabilities.

    Main Methods:

    • Theoretical modeling of selection dynamics.

    Related Experiment Videos

  • Analysis of genetic variance and response to selection.
  • Simulation studies exploring the impact of population size and initial allele frequencies.

    • Main Results:

    • A selection plateau is characterized by the presence of genetic variance.
    • The extent of response at the plateau is a function of the initial selection response and the intensity of natural selection.
    • In small populations, initial gene frequencies are as crucial as selection intensity for fixing desirable alleles.

    Conclusions:

    • Opposing selection pressures can maintain genetic variation, leading to selection plateaus.
    • Understanding the interplay between directional and natural selection is key to predicting evolutionary trajectories.
    • Population size and initial genetic architecture significantly influence the success of artificial selection programs.