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Preliminary communications.

C Stanciu, J R Bennett

    British Medical Journal
    |February 23, 1974
    PubMed
    Summary
    This summary is machine-generated.

    Pentazocine reduced colonic pressures in patients with irritable bowel syndrome and diverticular disease. This suggests pentazocine may be a safe alternative for managing colonic pain where morphine is contraindicated.

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    Area of Science:

    • Gastroenterology
    • Pharmacology

    Background:

    • Colonic motor activity influences abdominal pain in conditions like irritable bowel syndrome (IBS) and diverticular disease.
    • Opioid analgesics like morphine can exacerbate colonic pressures, making them unsuitable for pain management in these conditions.

    Purpose of the Study:

    • To investigate the effects of pentazocine on colonic motor activity.
    • To evaluate pentazocine's potential as an alternative analgesic for colonic pain.

    Main Methods:

    • Intraluminal colonic pressures were measured in healthy subjects and patients with IBS and diverticular disease.
    • The effects of pentazocine administration on these pressures were recorded.

    Main Results:

    • Pentazocine significantly decreased intraluminal colonic pressures in most participants.

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  • One subject did not exhibit a decrease in colonic pressures.

    • Conclusions:

    • Pentazocine demonstrates a hypotensive effect on colonic motor activity.
    • Pentazocine may be a viable therapeutic option for managing abdominal pain associated with IBS and diverticular disease, unlike morphine.