Related Experiment Video
Updated: Aug 18, 2026

A Galvanotaxis Assay for Analysis of Neural Precursor Cell Migration Kinetics in an Externally Applied Direct Current Electric Field
Published on: October 13, 2012
Migratory cell locomotion versus nerve axon elongation: differences based on the effects of lanthanum ion
Abstract:
The effects of lanthanum ions (La(+++)) on the locomotion and adhesion of g lial cells and elongating nerve axons are reported. La(+++) increases adhesion of both glia and of nerve growth cones to a plastic substratum. La(+++) also markedly reduces glia locomotion, but it does not inhibit nerve elongation. Electron-opaque deposits are seen on the cell surface and within cytoplasmic vesicles of glia and nerves cultured in a La(+++)-containing medium. Possible modes of action for La(+++) are discussed, particularly the possibilities that Ca(++) fluxes or Ca(++) involvement in adhesion are altered by La(+++). The results are consistent with the hypothesis that cell migration and nerve axon elongation differ in mechanism, with respect to both adhesive interactions and the activity of microfilament systems.
Related Concept Videos
Action Potentials
Cell Migration
Action Potential
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
Cell Migration
Action Potential
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
Propagation of Action Potentials
Neurons (nerve cells) have a resting membrane potential, with a slightly negative charge inside compared to outside. This is maintained by ion channels, such as sodium (Na+) and potassium (K+) channels, which control the flow of ions. When a stimulus, like a touch or a signal from another neuron, triggers the neuron, sodium channels open, allowing sodium ions to...

