Related Experiment Video
Updated: May 1, 2026

Mouse- and Human-derived Primary Gastric Epithelial Monolayer Culture for the Study of Regeneration
Published on: May 7, 2018
Extraction of circulating endogenous gastrin by the gastric fundus
Abstract:
The effect of circulatory transit of the gastric fundus on serum levels of endogenous gastrin measured directly by radioimmunoassay has been studied in 14 dogs. Gastrin was measured in samples obtained simultaneously from the arterial inflow and venous outflow of the gastric fundus. During basal conditions, transit of the gastric fundus resulted in no change in gastrin concentration. During periods of stimulated gastrin release from the antrum, nine of the 14 dogs demonstrated a significant gastric acid secretory response. In these dogs there was a significant arteriovenous difference (approximately 30%) in circulating gastrin values. In the remaining five dogs, which did not demonstrate a significant gastric acid secretory response, there was no arteriovenous difference in circulating gastrin values. It is concluded that the gastric fundus is an important site for the inactivation of stimulated levels of circulating gastrin.
More Related Videos
Related Concept Videos
Hormonal Regulation
Hormones Secreted by the Stomach
Each of these hormones secreted by different enteroendocrine cells plays a unique role in digestion. Here are a few examples:
Gastric Phase of Digestion
When food enters the stomach, it stretches the stomach walls and activates stretch receptors. This triggers local reflexes of the enteric nervous system, mediated through the myenteric plexus. These...
Intestinal Phase of Digestion
The arrival of the chyme in the small intestine distends the duodenum, which triggers the enterogastric reflex. This distension...
Gastric Emptying
Gastritis II: Pathophysiology

