Hydrolysis derivatives of (pyridyl-2)acetonitrile

The alkaline hydrolysis (KOH/EtOH) of alkyl derivatives of (pyridyl-2)acetonitriles gave the corresponding amides. Lactones: 3-(pyridyl-2')3-alkyl-5-methyl-tetrahydrofuran-2-ones were synthesized as result of the hydrolysis of (pyridyl-2) alkylallylacetamides in presence of 85% H3P04. Soporific and anticonvulsive activity exhibited (pyridyl-2)diallylacetic amide 2 and (pyridyl-2)di-n-propylacetamine 3.