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Leukocyte migration inhibition in chorioretinitis
Infection and Immunity
|May 1, 1974
Summary
Cell-mediated immunity was assessed in chorioretinal disease patients using the leukocyte migration inhibition (LMI) test. Retina antigens frequently triggered LMI, suggesting a role in the disorder's chronicity.
Area of Science:
- Ophthalmology
- Immunology
- Cellular Biology
Background:
- Chorioretinal diseases involve inflammation of the choroid and retina.
- Cell-mediated immunity is implicated in the pathogenesis of ocular inflammatory conditions.
Purpose of the Study:
- To investigate leukocyte migration inhibition (LMI) in response to choroid, retina, and uveal tract antigens in patients with active and quiescent chorioretinal disease.
- To assess the role of cellular immunity in the chronicity of chorioretinal disorders.
Main Methods:
- Leukocyte migration inhibition (LMI) test was performed on patients with active and quiescent chorioretinal disease.
- Antigens derived from choroid, retina, and pooled uveal tract tissue were used.
- Patients' immune responses were evaluated both during active inflammation and remission, with and without steroid therapy.
Main Results:
- Leukocyte migration inhibition (LMI) by retinal antigens was frequent, observed in 9/16 active and 8/15 quiescent disease patients.
- LMI by choroidal antigens occurred in 7/15 active inflammation patients off steroids and 3/13 with healed disease.
- Significant LMI was detected in patients with active (3/6) and past (1/5) chorioretinitis when tested with uveal tract antigens.
Conclusions:
- The LMI test indicates cell-mediated immunity.
- Retinal antigens frequently elicit LMI in chorioretinopathies, suggesting it's a secondary event.
- Cellular immunity to retinal antigens may contribute to the long-term persistence of chorioretinal disorders.