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Related Experiment Videos

Chronic recurrent angina.

R M Robertson, J B Breinig, D Robertson

    Southern Medical Journal
    |October 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Variant angina presents with variable ST elevation episodes, often asymptomatic. Clinical trials show no single agent effectively treats this condition, highlighting the need for rigorous study designs.

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    Area of Science:

    • Cardiology
    • Clinical Medicine

    Background:

    • Variant angina, also known as Prinzmetal's angina, is a condition characterized by recurrent chest pain due to transient coronary artery spasm.
    • Understanding the natural history and variability of variant angina is crucial for effective patient management and therapeutic development.

    Observation:

    • Continuous electrocardiographic monitoring revealed numerous ST elevation episodes, with a high percentage being asymptomatic.
    • Episode duration varied significantly, and some were associated with arrhythmias like premature ventricular contractions.
    • A decrease in the frequency and duration of ST elevation and pain episodes was observed during hospitalization.

    Findings:

    • Double-blind crossover trials evaluated propranolol, indomethacin, and chlorpheniramine.
    • No tested therapeutic agent demonstrated a significant beneficial effect on the disease course.

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  • High-dose propranolol was associated with an increase in episode duration.

    • Implications:

    • The significant variability in variant angina necessitates the use of robust study designs, such as double-blind crossover trials, to accurately assess treatment efficacy.
    • Current therapeutic options may have limited impact on the natural course of variant angina.
    • Further research is needed to identify effective treatments for this condition.