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Related Experiment Videos

Keratinosomes in psoriatic skin.

J H Mottaz, A S Zelickson

    Acta Dermato-Venereologica
    |January 1, 1975
    PubMed
    Summary

    Psoriatic skin shows increased numbers and altered morphology of keratinosomes compared to normal skin. These structures, involved in skin barrier function, exhibit unique developmental patterns in psoriasis.

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    Area of Science:

    • Dermatology
    • Cell Biology
    • Histology

    Background:

    • Keratinosomes are key structures in epidermal differentiation and skin barrier formation.
    • Alterations in keratinosome morphology and number may be associated with skin diseases like psoriasis.

    Purpose of the Study:

    • To investigate the morphological and numerical characteristics of keratinosomes in psoriatic skin.
    • To compare keratinosomes in psoriatic skin with those in normal skin.

    Main Methods:

    • Observational analysis of skin tissue samples.
    • Histological examination of keratinosome structures and distribution.

    Main Results:

    • Keratinosomes in psoriatic skin are often larger and exhibit unusual internal morphology compared to normal skin.
    • An increased number of keratinosomes is observed in psoriatic epidermis, including within sweat ducts.
    • Keratinosomes appear both intracellularly and extracellularly, from the spinous to the horny layer.

    Conclusions:

    • Psoriatic skin displays significant alterations in keratinosome characteristics.
    • These findings suggest a potential role for keratinosomes in the pathogenesis of psoriasis.

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