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Differential antibiotic excretion in unilateral structural pyelonephritis.
The Western Journal of Medicine
|May 1, 1974
Summary
Impaired antibiotic excretion occurs in the affected kidney of patients with unilateral pyelonephritis. Urinary antibiotic levels decrease with medullary damage, potentially limiting oral penicillin-G effectiveness for this condition.
Area of Science:
- Nephrology
- Pharmacology
- Infectious Diseases
Background:
- Unilateral pyelonephritis can lead to structural kidney damage.
- Antibiotic efficacy depends on achieving adequate drug concentrations at the infection site.
Purpose of the Study:
- To investigate antibiotic excretion in patients with unilateral pyelonephritis.
- To correlate antibiotic levels with renal function and treatment outcomes.
Main Methods:
- Differential antibiotic excretion studies were performed in eight patients.
- Renal function was assessed using differential renal function studies.
- Urinary antibiotic concentrations (peak and mean) were measured on affected and normal sides.
Main Results:
- All patients showed impaired antibiotic excretion on the affected side.
- Decreased peak and mean urinary antibiotic concentrations were observed in the structurally abnormal kidney.
- The degree of impaired excretion correlated with the extent of unilateral medullary damage.
Conclusions:
- Significant decreases in urinary antibiotic levels in unilateral pyelonephritis with renal damage may compromise treatment.
- Oral penicillin-G may be less effective in such cases due to suboptimal drug concentrations.