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Mebendazole.

J S Keystone, J K Murdoch

Annals of Internal Medicine

|October 1, 1979

Summary

This summary is machine-generated.

Mebendazole is a safe and effective anthelmintic, particularly for trichuriasis, enterobiasis, and hookworm infections. Its unique mechanism of microtubular destruction shows promise for treating multiple helminth infections.

Keywords:

Clinical Research Diseases Economic Factors Health Parasite Control Parasitic Diseases Public Health Research And Development Research Methodology Technology Treatment

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Area of Science:

Pharmacology
Infectious Diseases
Parasitology

Background:

Mebendazole is an anthelmintic with a broad spectrum of activity and a favorable safety profile.
Clinical experience over five years highlights its unique characteristics.

Purpose of the Study:

To review the efficacy and safety of mebendazole as an anthelmintic.
To discuss its mechanism of action and clinical applications.

Main Methods:

Review of clinical data and scientific literature on mebendazole.
Analysis of its mechanism of action (microtubular destruction) and glucose uptake inhibition in parasites.

Main Results:

Mebendazole is effective for trichuriasis, enterobiasis, and hookworm infections.
Poor absorption generally does not limit efficacy, except possibly in systemic infections.
Shows promise for capillariasis and hydatid disease, with further research needed for other helminthiases.

Conclusions:

Mebendazole is a valuable anthelmintic, especially for common infections and potentially for multiple helminth infections.
Its unique mechanism and safety profile support its continued use and exploration in new applications.