Effects of 1,3-bis(2-chloroethyl)-1-nitrosourea and related compounds on nuclear RNA metabolism

Dose-response transition from cell cycle arrest to apoptosis with selective degradation of Mdm2 and p21WAF1/CIP1 in response to the novel anticancer agent, aminoflavone (NSC 686,288).

Oncogene·2007

p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine.

Oncogene·2006

Quantitative structure-antitumor activity relationships of camptothecin analogues: cluster analysis and genetic algorithm-based studies.

Journal of medicinal chemistry·2001

How do drug-induced topoisomerase I-DNA lesions signal to the molecular interaction network that regulates cell cycle checkpoints, DNA replication, and DNA repair?

Cell biochemistry and biophysics·2001

Molecular and biological determinants of the cytotoxic actions of camptothecins. Perspective for the development of new topoisomerase I inhibitors.

Annals of the New York Academy of Sciences·2001

Effects of c-erbB2 overexpression on the drug sensitivities of normal human mammary epithelial cells.

Journal of the National Cancer Institute·2000

Spatial Transcriptomics on a Diverse Pancreatic Cancer Cohort Reveals Race-Related Differences in Tumor Subtypes and Immune Microenvironments.

Cancer research·2026

Mechanical Stress Induces Nuclear Envelope Rupture in Melanoma Cells to Reorganize Tumor-Stromal Interactions.

Cancer research·2026

Beyond Internalization: Target Binding as the Trigger.

Cancer research·2026

Antiviral T cells doing double-duty to fight cancer.

Cancer research·2026

MEKing Room: On the Quest for New Sources of Therapeutic Index in RAS/MAPK-Driven Cancers.

Cancer research·2026

ACKR3 Establishes a Squamous-Restricted Immune Checkpoint Axis in Lung Squamous Cell Carcinoma.

Cancer research·2026

Micro/nanoplastics: from synthesis to assimilation, global environmental impacts, challenges, consequences, and advanced remediation strategies.

RSC advances·2026

Endocrine-disrupting chemicals in male reproductive health: exposure risks, reproductive toxicity and emerging perspectives.

Frontiers in endocrinology·2026

Global research trends on RF-EMR and reproductive health: Bibliometric insights and mechanistic review.

Biochemistry and biophysics reports·2026

Olfactory dysfunction among gas station employees exposed to fuel vapors using digital odor identification testing.

iScience·2026

Metal Accumulation, Liver Histopathology, and Human Health Risk Assessment Across Different Trophic Guilds in a Mining-Affected Neotropical River.

Journal of applied toxicology : JAT·2026

Behavior and Toxicity of Buckminsterfullerene (C60) in Aquatic Environments: A 30-Year Review.

Environmental research·2026

Related Experiment Videos

Effects of 1,3-bis(2-chloroethyl)-1-nitrosourea and related compounds on nuclear RNA metabolism

Related Concept Videos

Dose-response transition from cell cycle arrest to apoptosis with selective degradation of Mdm2 and p21WAF1/CIP1 in response to the novel anticancer agent, aminoflavone (NSC 686,288).

p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine.

Quantitative structure-antitumor activity relationships of camptothecin analogues: cluster analysis and genetic algorithm-based studies.

How do drug-induced topoisomerase I-DNA lesions signal to the molecular interaction network that regulates cell cycle checkpoints, DNA replication, and DNA repair?

Molecular and biological determinants of the cytotoxic actions of camptothecins. Perspective for the development of new topoisomerase I inhibitors.

Effects of c-erbB2 overexpression on the drug sensitivities of normal human mammary epithelial cells.

Spatial Transcriptomics on a Diverse Pancreatic Cancer Cohort Reveals Race-Related Differences in Tumor Subtypes and Immune Microenvironments.

Mechanical Stress Induces Nuclear Envelope Rupture in Melanoma Cells to Reorganize Tumor-Stromal Interactions.

Beyond Internalization: Target Binding as the Trigger.

Antiviral T cells doing double-duty to fight cancer.

MEKing Room: On the Quest for New Sources of Therapeutic Index in RAS/MAPK-Driven Cancers.

ACKR3 Establishes a Squamous-Restricted Immune Checkpoint Axis in Lung Squamous Cell Carcinoma.

Micro/nanoplastics: from synthesis to assimilation, global environmental impacts, challenges, consequences, and advanced remediation strategies.

Endocrine-disrupting chemicals in male reproductive health: exposure risks, reproductive toxicity and emerging perspectives.

Global research trends on RF-EMR and reproductive health: Bibliometric insights and mechanistic review.

Olfactory dysfunction among gas station employees exposed to fuel vapors using digital odor identification testing.

Metal Accumulation, Liver Histopathology, and Human Health Risk Assessment Across Different Trophic Guilds in a Mining-Affected Neotropical River.

Behavior and Toxicity of Buckminsterfullerene (C60) in Aquatic Environments: A 30-Year Review.

Related Experiment Videos

Effects of 1,3-bis(2-chloroethyl)-1-nitrosourea and related compounds on nuclear RNA metabolism

Related Concept Videos

Related Articles