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Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry

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How do tears drain? Technetium studies.

G Theodossiadis, M Panopoulos, D Chatzoulis

Canadian Journal of Ophthalmology. Journal Canadien D'Ophtalmologie

|July 1, 1979

Summary

This study used scintillography to visualize normal tear drainage in volunteers. Findings confirm tear movement from the lacrimal sac to the nasolacrimal duct upon eyelid opening.

Area of Science:

Ophthalmology
Nuclear Medicine

Background:

Understanding the tear drainage pathway is crucial for diagnosing and treating ocular surface diseases.
Previous models of tear drainage exist, but dynamic visualization is key.

Purpose of the Study:

To investigate the dynamic process of normal tear drainage using radioactive tracer imaging.
To evaluate the role of eyelid movement in tear flow through the lacrimal sac and nasolacrimal duct.

Main Methods:

Scintillography with Technetium Tc 99m (Pertechnetate) was performed on 25 healthy volunteers.
Dynamic imaging captured tracer behavior in the lacrimal sac and nasolacrimal duct during eyelid closure and opening.
Photographic documentation supplemented the scintigraphic data.

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Main Results:

The tracer concentrated in the lacrimal sac during a 3-minute eyelid closure period.
Upon eyelid opening, the tracer rapidly descended into the nasolacrimal duct.
Eyelid movement was directly correlated with tear flow dynamics.

Conclusions:

The observed tear drainage patterns support established theories, particularly Jones' views on normal tear flow.
Dynamic scintillography provides valuable insights into the functional anatomy of the tear drainage system.
Eyelid blinking plays a significant role in propelling tears through the nasolacrimal system.