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A computer program for survival comparisons to a standard population.

S Y Moon, R F Woolson, J A Bean

    Computer Programs in Biomedicine
    |September 1, 1979
    PubMed
    Summary
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    PROPHAZ is a new computer program for survival data analysis using the general proportional hazards model. It estimates hazard functions from population mortality data and calculates regression coefficients for variable analysis.

    Area of Science:

    • Biostatistics
    • Survival Analysis
    • Computational Statistics

    Background:

    • Survival data analysis is crucial in many scientific fields.
    • The general proportional hazards model offers a flexible framework for analyzing survival data.
    • Estimating hazard functions from reference populations provides valuable context.

    Purpose of the Study:

    • To introduce PROPHAZ, a novel computer program for survival data analysis.
    • To facilitate the application of the general proportional hazards model.
    • To enable hazard function estimation using external mortality data.

    Main Methods:

    • The program utilizes the general proportional hazards model.
    • It employs the Newton-Raphson method for iterative regression coefficient calculation.

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  • Chi-squared (x2) statistics are derived using large sample asymptotic theory for hypothesis testing.

    • Main Results:

    • PROPHAZ provides regression coefficients for user-defined variables.
    • It generates chi-squared statistics for hypothesis testing (C beta = 0).
    • The program accommodates flexible input formats for variables and mortality data.

    Conclusions:

    • PROPHAZ offers a robust computational tool for survival data analysis.
    • Its design allows for integration with external mortality data for hazard function estimation.
    • The program supports hypothesis testing within the proportional hazards framework.