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Related Experiment Videos

Opiate stimulation increases exploration in the mouse.

R J Katz

    The International Journal of Neuroscience
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Morphine sulfate increased exploratory behaviors like rearing and nose poking in mice. This indicates that opiates play a role in behavioral arousal and exploration.

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Behavioral Science

    Background:

    • Opiates are known for their analgesic properties.
    • Their role in modulating complex behaviors like exploration is less understood.

    Purpose of the Study:

    • To investigate the effect of a low dose of morphine sulfate on exploratory behavior in adult male Swiss-Webster mice.
    • To determine if opiates are involved in behavioral arousal and exploration.

    Main Methods:

    • Adult male Swiss-Webster mice were administered a low dose of morphine sulfate or a vehicle control.
    • Exploratory behavior was assessed using an apparatus measuring rearing and nose poking during a brief exposure period.

    Main Results:

    • Mice treated with morphine sulfate exhibited a significant increase in both rearing and nose poking behaviors.

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  • Vehicle-treated mice showed no significant changes in exploratory behaviors.

    • Conclusions:

    • The findings suggest a direct involvement of opiates in enhancing behavioral arousal.
    • Specifically, opiates appear to modulate and increase exploratory behaviors, such as rearing and nose poking.