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Related Experiment Videos

Ascorbic acid and vitamin B12.

H L Newmark, J M Scheiner, M Marcus

    JAMA
    |November 23, 1979
    PubMed
    Summary
    This summary is machine-generated.

    High doses of ascorbic acid do not impact vitamin B12 stability in the stomach. Studies show vitamin B12 remains unchanged when meals with ascorbic acid are incubated, mimicking gastric conditions.

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    Area of Science:

    • Nutrition Science
    • Biochemistry

    Background:

    • Vitamin B12 is essential for human health.
    • Ascorbic acid (vitamin C) is commonly consumed.
    • Potential interactions between vitamin B12 and ascorbic acid require investigation.

    Purpose of the Study:

    • To determine if ascorbic acid affects vitamin B12 stability under simulated gastric conditions.

    Main Methods:

    • Meals containing vitamin B12 were incubated with ascorbic acid at 37°C for 30 minutes.
    • Extraction procedures utilized cyanide or metabisulfite for vitamin B12 protection.
    • Comparison with previous studies reporting degradation.

    Main Results:

    • No change in vitamin B12 levels was observed when protected during extraction.

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  • Previous reports of degradation were attributed to incomplete protection methods.
  • Laboratory conditions mimicked the human gastric environment.

    • Conclusions:

    • Ascorbic acid does not degrade vitamin B12 in the gastric environment.
    • High doses of ascorbic acid are safe concerning vitamin B12 stability in vivo.