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[beta2-Microglobulin in healthy children and in children with renal diseases (author's transl)]
Zeitschrift Fur Kinderheilkunde
|January 1, 1975
Insights
Beta-2 microglobulin (B2M) levels in serum and urine can indicate kidney function. Elevated serum B2M suggests reduced glomerular filtration rate (GFR), while increased urinary B2M indicates tubular damage.
Area of Science:
- Nephrology
- Clinical Chemistry
- Biomarker Research
Abstract:
beta2 microglobulin is a plasma protein of low molecular weight (11800), which also appears in urine in small quantities and cerebrospinal fluid. Its serum concentration in healthy children is 0.12 plus or minus 0.04 mg/100 ml, its renal excretion is 0.07 plus or minus 0.05 mg/24 hrs. In glomerular nephropathy serum levels are augmented with diminished GFR, while in tubular nephropathy excretion in the urine is raised considerably. There is a close correlation between serum beta2 microglobulin and GFR.