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Plasma calcitonin in renal osteodystrophy.

S M Chittal, D G Oreopoulos, G A DeVeber

    Canadian Medical Association Journal
    |June 19, 1971
    PubMed
    Summary

    Plasma calcitonin-like activity (CLA) is normal in chronic renal failure patients and does not correlate with bone disease. However, normal CLA may help protect the skeleton from high parathyroid hormone levels.

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    Area of Science:

    • Nephrology
    • Endocrinology
    • Bone Metabolism

    Background:

    • Renal osteodystrophy is a common complication in chronic renal failure (CRF).
    • The role of calcitonin in the pathogenesis of renal osteodystrophy remains unclear.
    • Parathyroid hormone levels are typically elevated in CRF patients, potentially impacting bone health.

    Purpose of the Study:

    • To investigate the role of calcitonin in the pathogenesis of renal osteodystrophy.
    • To measure plasma calcitonin-like activity (CLA) in patients with CRF.
    • To assess the correlation between plasma CLA, bone lesions, and clinical parameters in CRF.

    Main Methods:

    • Plasma calcitonin-like activity (CLA) was measured using an extraction procedure and bioassay.
    • 17 patients with chronic renal failure were studied.

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  • Bone biopsy data were available for 11 patients.

    • Main Results:

    • Plasma CLA was found to be within the normal range in patients with CRF.
    • A strong positive correlation was observed between plasma calcium and plasma CLA.
    • Neither chronic dialysis nor renal transplantation significantly affected plasma CLA.
    • The severity and type of bone lesions did not correlate with plasma CLA.

    Conclusions:

    • Plasma calcitonin does not appear to be directly implicated in the pathogenesis of renal osteodystrophy.
    • Normal calcitonin levels may offer some skeletal protection against elevated parathyroid hormone in CRF.
    • Further research is needed to fully elucidate the role of calcitonin in CRF bone disease.