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Ethanol consumption and hepatic enzyme activity.

S M Anderson, G E McClearn, V G Erwin

    Pharmacology, Biochemistry, and Behavior
    |July 1, 1979
    PubMed
    Summary
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    Researchers found a link between alcohol dehydrogenase activity and ethanol consumption in mice. Selective breeding created high and low ethanol acceptance lines, with higher enzyme activity in the high acceptance group.

    Area of Science:

    • Genetics
    • Neuroscience
    • Pharmacology

    Background:

    • Ethanol consumption is influenced by genetic factors.
    • Alcohol dehydrogenase (ADH) is a key enzyme in ethanol metabolism.

    Purpose of the Study:

    • To investigate the relationship between alcohol dehydrogenase activity and ethanol acceptance in mice.
    • To establish and characterize mouse lines with differing ethanol acceptance.

    Main Methods:

    • Cross-breeding C57BL and C3H mice to create an F2 generation.
    • Measuring alcohol dehydrogenase activity and ethanol acceptance.
    • Selective breeding of a genetically heterogeneous stock (HS/Ibg) to develop high (HEA) and low (LEA) ethanol acceptance lines.

    Main Results:

    Related Experiment Videos

    • A significant correlation (0.25) was observed between alcohol dehydrogenase activity and ethanol acceptance in the F2 generation.
    • After five generations, HEA mice exhibited 24% higher liver alcohol dehydrogenase activity compared to LEA mice.
    • No association was found between cytosolic aldehyde dehydrogenase activity and ethanol acceptance.

    Conclusions:

    • Alcohol dehydrogenase activity is associated with ethanol acceptance in mice.
    • Selective breeding can effectively alter ethanol acceptance and related enzyme activity.
    • Cytosolic aldehyde dehydrogenase activity does not appear to play a significant role in ethanol acceptance.