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Related Experiment Videos

Contractility of the urinary bladder.

R van Mastrigt, D J Griffiths

    Urologia Internationalis
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    This study models pig bladder contractility using a series elastic and contractile element model. Findings reveal force-velocity relationships and non-linear elasticity, informing bladder function assessments.

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    Area of Science:

    • Urology
    • Biomedical Engineering
    • Physiology

    Background:

    • Assessing bladder contractility is crucial for diagnosing and managing lower urinary tract symptoms.
    • Current clinical methods for evaluating bladder function have limitations in accurately capturing active mechanical properties.

    Purpose of the Study:

    • To investigate the active mechanical properties of complete pig bladders in vitro.
    • To model the bladder wall using a series of contractile and elastic elements.
    • To inform the development of improved clinical methods for assessing bladder contractility.

    Main Methods:

    • In vitro mechanical testing of electrically stimulated pig bladders.
    • Utilizing a biomechanical model comprising a contractile element and a series elastic element.

    Related Experiment Videos

  • Applying the Hill equation to describe the force-velocity relationship of the contractile element.
  • Characterizing the non-linear force-extension relationship of the series elastic element.

    • Main Results:

    • The active force of the contractile element is dependent on its velocity of shortening, well-described by the Hill equation when normalized.
    • The series elastic element exhibits a non-linear force-extension relationship.
    • An elastic modulus dependent on monoexponential extension characterizes the series elastic element.

    Conclusions:

    • The developed model provides a detailed understanding of bladder wall mechanics during contraction.
    • The findings highlight limitations in current clinical assessments of bladder contractility.
    • This research paves the way for novel, more accurate methods for evaluating bladder function.