[Study of intravenous amitriptyline in acute depressions (author's transl)]

The author has performed an open study of 27 patients with an acute depressive state, hospitalized and treated with slow intravenous perfusions of amitriptyline. Similar perfusions of chlorimipramine act certainly more rapidly on depression, but conversion to oral dose raises some problems regarding active dosis. Intravenous amitriptyline reduces latency, is more sedative and without major intolerance, such as hemodynamic. Conversion to oral diffused forms (Redomex diffucaps) consolidates the results obtained by parenteral administration, and the antianxiety component permits the use of this drug in monotherapy.