An inhibitor of lipid peroxidation in rat lungs

Formation of lipid peroxides in vitro was investigated in the lung, liver, and brain homogenates of normal male rats. Unlike brain tissue, increasing the concentration of lung or liver in homogenates resulted in decreased output of lipid peroxides. Further, lung homogenates exerted an inhibition of lipid peroxide formation by brain and dilute liver homogenates. The factor responsible for such inhibition was located in the postmitochondrial supernatant, was heat stable, nondialysable, could be preserved in frozen state for 60 days, concentrated by dialysis against powdered sucrose, and precipitated by ammonium sulphate.