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Coronary anaphylaxis in vitro.

N Chand, P Eyre

    British Journal of Pharmacology
    |October 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Calf coronary arteries and cardiac veins react to anaphylaxis mediators. A new anti-allergic agent, Compound PRD-92-EA, inhibited anaphylactic reactions, suggesting its therapeutic potential.

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    Area of Science:

    • Cardiovascular Pharmacology
    • Immunopharmacology
    • Anaphylaxis Research

    Background:

    • Anaphylaxis involves complex physiological responses, including vascular changes.
    • Understanding the specific reactivity of cardiac vessels during anaphylaxis is crucial for developing targeted therapies.

    Purpose of the Study:

    • To investigate the contractile and relaxant responses of isolated calf coronary arteries and cardiac veins to anaphylaxis mediators and antigen.
    • To evaluate the efficacy of a novel anti-allergic agent, Compound PRD-92-EA, in modulating anaphylactic reactions in coronary vessels.

    Main Methods:

    • Isolated coronary arteries and cardiac veins from calves were exposed to various chemical mediators (bradykinin, 5-hydroxytryptamine, prostaglandins, histamine, carbachol) and horse plasma (antigen).
    • Vessel responses (contraction/relaxation) were measured.

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  • The effects of specific antagonists and Compound PRD-92-EA on anaphylactic reactions were assessed.

    • Main Results:

    • Both coronary arteries and cardiac veins contracted in response to bradykinin, 5-hydroxytryptamine (5-HT), prostaglandin E2 (PGE2), PGF2 alpha, histamine, and carbachol.
    • Isoprenaline and prostaglandin E1 (PGE1) induced relaxation in pre-contracted vessels.
    • Horse plasma induced contraction in sensitized calf coronary vessels, with subsequent desensitization observed.
    • Atropine, mepyramine (H1-blocker), and methysergide did not significantly alter the anaphylactic reaction.
    • Compound PRD-92-EA demonstrated non-specific receptor blocking activity and inhibited the coronary anaphylactic reaction.

    Conclusions:

    • Calf coronary arteries and cardiac veins exhibit significant reactivity to various anaphylaxis mediators.
    • The anaphylactic response in coronary vessels involves mechanisms not solely dependent on histamine, 5-HT, or cholinergic pathways.
    • Compound PRD-92-EA shows promise as an anti-allergic agent by inhibiting coronary anaphylactic reactions.