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Autoimmunity in degenerative disk disease. A histopathologic study.

E P Urovitz, V L Fornasier

Clinical Orthopaedics and Related Research

|July 1, 1979

Summary

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Degenerative disc disease may not stem from autoimmune issues. A histopathologic study found no immune cells, suggesting mechanical injury is a more likely cause for disc degeneration.

Area of Science:

Orthopedics
Immunology
Pathology

Background:

Recent in vitro studies proposed an autoimmune basis for degenerative disc disease.
This hypothesis requires further investigation through in vivo studies.

Purpose of the Study:

To histopathologically examine intervertebral disc specimens for evidence of autoimmune involvement.
To investigate the cellular infiltrate in Schmorl's nodes and degenerated intervertebral discs.

Main Methods:

Histopathologic examination of 218 specimens (108 Schmorl's nodes, 110 intervertebral discs).
Analysis for immune-reaction type inflammatory cellular infiltrate.

Main Results:

No inflammatory cellular infiltrates were detected in any specimens.

Related Experiment Videos

Granulation tissue ingrowths and vascular invasion were observed.

Conclusions:

The findings do not support an autoimmune basis for degenerative disc disease.
Observed pathologies likely represent the body's response to mechanical injury, not an inflammatory response to an antigen.