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A glucose-controlled insulin-delivery system: semisynthetic insulin bound to lectin
Science (New York, N.Y.)
|December 7, 1979
Abstract:
A stable, biologically active glycosylated insulin derivative that is complementary to the major combining site of concanavalin A has been synthesized. Hormone release is proportional to the quantity of glucose present. Glucose regulation of exogenous insulin delivery could have important applications in the therapy of diabetes mellitus.