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Acute hepatic coma successfully treated by extracorporeal baboon liver perfusions
British Medical Journal
|January 1, 1972
Summary
Extracorporeal baboon liver perfusion safely and effectively treated two patients with acute hepatic coma from viral hepatitis, restoring consciousness and leading to full recovery. This xenotransplantation method offers a promising alternative for liver failure treatment.
Area of Science:
- Hepatology
- Transplantation Medicine
- Critical Care
Background:
- Fulminant viral hepatitis can lead to severe hepatic coma.
- Medical treatments and exchange transfusions may be insufficient for acute liver failure.
Purpose of the Study:
- To evaluate the safety and efficacy of extracorporeal baboon liver perfusion in patients with hepatic coma.
- To assess the potential of xenotransplantation as a treatment for acute liver failure.
Main Methods:
- Two patients with hepatic coma underwent extracorporeal baboon liver perfusion.
- Treatment outcomes, including consciousness, recovery, and immunological reactions, were monitored.
Main Results:
- Both patients regained consciousness after a single liver perfusion session.
- Complete recovery was observed, with patients leading normal lives months post-treatment.
- Perfusion was well-tolerated, with no clinical immunological reactions or antibaboon antibodies detected.
Conclusions:
- Extracorporeal baboon liver perfusion is a safe and effective treatment for acute hepatic coma.
- This xenotransplantation approach can restore normal consciousness and facilitate recovery in severe liver failure.