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Reiter's disease and the histocompatibility antigen, HL-A 27
Scandinavian Journal of Rheumatology
|January 1, 1975
Summary
Human Leukocyte Antigen (HLA)-27 is strongly associated with Reiter's disease. This finding suggests HLA-27 may indicate a genetic susceptibility to certain types of reactive arthritis.
Area of Science:
- Immunogenetics
- Rheumatology
- Arthritis Research
Background:
- Reiter's disease is a form of reactive arthritis.
- Ankylosing spondylitis and psoriatic arthritis share features with reactive arthritis.
Purpose of the Study:
- To investigate the association between HLA-27 and Reiter's disease.
- To explore the potential genetic basis for susceptibility to reactive arthritis.
Main Methods:
- Case-control study design.
- Human Leukocyte Antigen (HLA) typing performed on patients and controls.
Main Results:
- HLA-27 was present in 65% of Reiter's disease patients.
- Only 8% of healthy controls carried the HLA-27 antigen.
- A significant association was found between HLA-27 and Reiter's disease.
Conclusions:
- HLA-27 is closely linked to the genetic predisposition for Reiter's disease.
- This genetic factor may influence immune responses, increasing susceptibility to reactive arthritis.
- The findings support a shared immunogenetic pathway between Reiter's disease, ankylosing spondylitis, and certain psoriatic arthritis cases.