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Effects of antineoplastic agents on wound healing in mice
Abstract:
The influence of antineoplastic agents on wound healing was evaluated in an experimental model employing surgical incisions in the skin of mice. A single injection in the therapeutic dose range of various clinically active antitumor agents was administered immediately following operation and the breaking strength of skin wounds was measured 3, 7, and 21 days later. Vincristine and methotrexate decreased wound strength at 3 days but not on days 7 or 21. Actinomycin D interfered with early phases of wound healing and had less effect on later phases. Treatment with bleomycin had no effect on wound strength at days 3 or 21 but prevented an increase in wound strength from day 3 to day 7; 1,3-bis(2-choroethyl)-1-nitrosurea (BCNU) decreased wound strength at all time points after operation, whereas 5-Fluorouracil had no significant effect at any time. The presence of a large tumor mass had no direct effect on wound strength nor did it modify the effect on wound strength of an antineoplastic agent, cyclophosphamide. These findings are discussed, taking into account the experimental and clinical literature on the effects of antitumor drugs on wound healing.
Insights
Antineoplastic agents impact wound healing differently. Some drugs like vincristine and methotrexate temporarily reduce wound strength, while others like BCNU show lasting effects.
Area of Science:
- Oncology
- Wound Healing Research
- Pharmacology
Background:
- Antineoplastic agents are crucial in cancer treatment.
- Understanding their impact on wound healing is vital for patient care.
Purpose of the Study:
- To evaluate the effects of various antineoplastic agents on the breaking strength of skin wounds in a mouse model.
- To determine the time-dependent influence of these agents on wound repair.
Main Methods:
- Surgical incisions were made in mice.
- Therapeutic doses of antineoplastic agents were administered post-operation.
- Skin wound breaking strength was measured at 3, 7, and 21 days.
Main Results:
- Vincristine and methotrexate reduced wound strength at 3 days.
- Actinomycin D affected early wound healing phases.
- Bleomycin transiently inhibited wound strength increase; BCNU decreased strength at all time points.
- 5-Fluorouracil and cyclophosphamide showed no significant effects.
Conclusions:
- Different antineoplastic agents have varied effects on wound healing.
- Drug-specific and time-dependent impacts on wound strength were observed.
- Tumor burden did not directly influence wound strength or drug effects.