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Updated: Aug 19, 2026

Quantifying Pulmonary Microvascular Density in Mice Across Lobules
Published on: January 3, 2025
Basal lamina of alveolar epithelium and capillaries: quantitative changes with aging and in diabetes mellitus
Abstract:
Epithelial and capillary basal laminae (BL) of alveoli are significantly thicker in diabetics than they are in age-matched control subjects. The degree of thickening does not correlate significantly with patient age or with known duration of diabetes. The thickness of both types of BL in the lungs correlates significantly with thickness of BL in renal tubules and muscle capillaries. However, in muscle capillaries and in renal tubules, the BL deposits are 5 to 10 times greater than they are in the lungs. The effects of BL changes on pulmonary function remain to be explored.
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