The effects of methyl-3-O-methyl gallate on isolated nerve activity

Methyl-3-O-methyl gallate (M30MG), extracted from Crinodendron hookerianum Gay, decreased both sciatic nerve accommodation and the amplitude of the compound action potential and increased the threshold to rectangular and exponential currents applied to the isolated sciatic nerve in a manner similar to that observed when tetrodotoxin is applied to the nerve. M30MG would act mainly on the large nerve fibres by a mechanism probably resembling that of tetrodotoxin.