Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lactic acidosis and liver disease.

R E Heinig, E F Clarke, C Waterhouse

    Archives of Internal Medicine
    |November 1, 1979
    PubMed
    Summary

    Hepatic insufficiency, both acute and chronic, can cause lactic acidosis. Acute liver failure showed more severe liver function test alterations and slightly better survival than chronic insufficiency with precipitating events.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    How patent law reform can improve affordability and accessibility of medicines in South Africa: Four medicine case studies.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2019
    Same author

    Surveillance of infection associated with external ventricular drains: proposed methodology and results from a pilot study.

    The Journal of hospital infection·2016
    Same author

    Successful pregnancy after liver transplantation in progressive familial intrahepatic cholestasis, type 1.

    Pediatric transplantation·2010
    Same author

    Kidney function studies in adrenal insufficiency.

    The Journal of clinical investigation·2010
    Same author

    Building Canada's health research capacity within the framework of the Canadian Institutes of Health Research.

    Paediatrics & child health·2010
    Same author

    The Glasgow Coma Scale and other neurological observations.

    Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2005

    Area of Science:

    • Hepatology
    • Critical Care Medicine
    • Biochemistry

    Background:

    • Hepatic insufficiency can lead to lactate accumulation and lactic acidosis.
    • Distinguishing between acute and chronic hepatic insufficiency is crucial for prognosis and management.
    • Lactic acidosis in liver disease requires careful evaluation of underlying causes and severity.

    Purpose of the Study:

    • To compare the clinical characteristics and outcomes of patients with acute versus chronic hepatic insufficiency presenting with lactic acidosis.
    • To identify predictors of survival in patients with liver disease and lactic acidosis.

    Main Methods:

    • Retrospective comparison of patients with acute hepatic failure and chronic hepatic insufficiency.
    • Analysis of hepatic function tests, precipitating events, and survival rates.
    • Evaluation of the impact of glucose administration on lactate levels.

    Main Results:

    • Patients with chronic hepatic insufficiency often had an acute precipitating event (sepsis, GI hemorrhage) with less dramatic liver function test alterations and no long-term survivors.
    • Patients with acute hepatic failure exhibited striking alterations in liver function tests, notably prolonged prothrombin time, with a 3/7 survival rate.
    • Hypoglycemia was common in both groups; glucose administration rapidly lowered lactate in two acute cases.

    Conclusions:

    • Acute hepatic failure presents with more severe hepatic dysfunction and a better, though limited, survival rate compared to chronic hepatic insufficiency with precipitating events.
    • Prothrombin time prolongation is an early and significant indicator in acute hepatic failure.
    • Management of hypoglycemia and prompt identification of precipitating events are critical in patients with hepatic insufficiency and lactic acidosis.

    Related Experiment Videos