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[Morphological changes of platelets in disturbed cerebral microcirculation--a clinical study using a scanning
No to Shinkei = Brain and Nerve
|September 1, 1979
Summary
Activated platelets in cerebral blood correlate with impaired consciousness in acute brain injury. These platelet changes, observed in cerebral blood but not systemic circulation, suggest a role in microcirculatory disturbances.
Area of Science:
- Neurology
- Hematology
- Pathophysiology
Context:
- Cerebral microcirculatory disturbances are multifactorial.
- The role of intravascular components, specifically platelets, in pathogenesis is under-investigated.
Purpose:
- To evaluate morphological changes in platelets within cerebral blood versus systemic blood.
- To correlate these platelet changes with neurological status, particularly consciousness levels, in patients with intracranial lesions.
Summary:
- Scanning electron microscopy revealed significantly activated platelet forms in cerebral venous blood (internal jugular vein) of patients with severe consciousness impairment during the acute stage of intracranial organic lesions.
- These platelet morphological changes were absent in systemic blood (cubital vein) and in patients with less severe neurological deficits.
- Platelet activation in cerebral blood diminished in the chronic stage, suggesting an acute-phase phenomenon linked to neurological damage.
Impact:
- Morphological platelet changes in cerebral blood are strongly associated with the severity of neurological damage, especially consciousness levels, in the acute phase.
- Activated platelets may contribute to cerebral microcirculatory disturbances through mechanical obstruction or release of vasoconstrictive substances.
- Findings suggest considering the role of activated platelets in the pathogenesis and treatment of intracranial organic lesions.