Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Exercise testing in men with significant left main coronary disease.

J V Nixon, K Lipscomb, C G Blomqvist

    British Heart Journal
    |October 1, 1979
    PubMed
    Summary

    The absence of exercise-induced ischemia virtually rules out left main coronary artery disease. Exercise performance did not correlate with symptom severity in patients with left main disease.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Non-Q-wave myocardial infarction.

    Postgraduate medicine·2017
    Same author

    Human baroreflex rhythms persist during handgrip and muscle ischaemia.

    Acta physiologica (Oxford, England)·2013
    Same author

    Laboratory and Clinical Observations on the Scalene "Accessory" Respiratory Muscles.

    Transactions of the American Clinical and Climatological Association·2011
    Same author

    Circumferential involvement of an acute type B aortic dissection: a unique case.

    Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography·2007
    Same author

    Simultaneous determination of the accuracy and precision of closed-circuit cardiac output rebreathing techniques.

    Journal of applied physiology (Bethesda, Md. : 1985)·2007
    Same author

    Predictors of the response to treatment in anemic hemodialysis patients with high serum ferritin and low transferrin saturation.

    Kidney international·2007

    Area of Science:

    • Cardiology
    • Exercise Physiology

    Background:

    • Left main coronary artery disease (LMCA) is a severe condition.
    • Distinguishing LMCA from multi-vessel disease using exercise tests is crucial for timely intervention.

    Purpose of the Study:

    • To compare exercise test responses in patients with left main disease versus those with two-vessel or three-vessel coronary artery disease.
    • To determine if exercise-induced ischemia can reliably identify left main disease.

    Main Methods:

    • Retrospective analysis of exercise test data from 26 patients with LMCA, 51 with three-vessel disease, and 38 with two-vessel disease.
    • Comparison of exercise-induced ischemia (chest pain, ST-segment changes), peak workload, and peak heart rate between groups.
    • Assessment of propranolol's effect on exercise test parameters.

    Main Results:

    • 100% of LMCA patients exhibited exercise-induced ischemia, compared to 69% with three-vessel and 45% with two-vessel disease.
    • Absence of abnormal electrocardiographic response during exercise effectively excluded LMCA.
    • No significant correlation between exercise performance and symptom severity in LMCA patients.
    • Propranolol did not alter the frequency of ischemic responses in LMCA or three-vessel disease.

    Conclusions:

    • Exercise testing is a valuable tool for excluding left main coronary artery disease.
    • Exercise capacity does not correlate with symptom severity in patients with left main disease.
    • Propranolol does not influence the ischemic response during exercise in patients with significant coronary artery disease.

    Related Experiment Videos