Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Amniotic fluid squalene and fetal maturity.

S J Wysocki, R Hähnel, M J Millward

    British Journal of Obstetrics and Gynaecology
    |November 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A phase 1b clinical trial of the CD40-activating antibody CP-870,893 in combination with cisplatin and pemetrexed in malignant pleural mesothelioma.

    Annals of oncology : official journal of the European Society for Medical Oncology·2015
    Same author

    The aggregation of early-onset melanoma in young Western Australian families.

    Cancer epidemiology·2015
    Same author

    Mycobacterium mimicking metastatic melanoma.

    Internal medicine journal·2013
    Same author

    Microwave Doppler Radar for Cardiac and Respiratory Activity Measurement - Preliminary Results.

    Biomedizinische Technik. Biomedical engineering·2013
    Same author

    The interaction between protein-kinase-C (pkc) and estrogens (review).

    International journal of oncology·2011
    Same author

    Prospective-study of stromelysin-3 expression in breast-cancer biopsies and disease-free survival.

    International journal of oncology·2011

    Amniotic fluid analysis revealed increased squalene levels in late-term pregnancies. The squalene-to-cholesterol ratio accurately predicts gestational age, aiding in the management of overdue pregnancies.

    Area of Science:

    • Biochemistry
    • Obstetrics
    • Analytical Chemistry

    Background:

    • Amniotic fluid composition changes during pregnancy.
    • Lipid profiles offer insights into fetal development and gestational status.

    Purpose of the Study:

    • To investigate neutral lipid profiles in amniotic fluid during late pregnancy.
    • To determine if lipid ratios can predict gestational age, specifically identifying post-term pregnancies.

    Main Methods:

    • Gas chromatography was used to analyze neutral lipids in 51 amniotic fluid samples.
    • Lipid profiles were examined from the last two months of gestation.
    • Squalene and cholesterol levels were quantified and their ratio (S/C) calculated.

    Main Results:

    Related Experiment Videos

    • A significant increase in squalene relative to other neutral lipids was observed in amniotic fluid at term.
    • The squalene-to-cholesterol (S/C) ratio effectively differentiated between pregnancies at or beyond 40 weeks gestation.
    • Elevated S/C ratios and squalene levels correlated with pregnancies several weeks overdue.

    Conclusions:

    • The squalene-to-cholesterol ratio in amniotic fluid is a reliable biomarker for predicting advanced gestational age.
    • This lipid analysis method can aid in the clinical management of post-term pregnancies.
    • Monitoring neutral lipid profiles offers a novel approach to assessing pregnancy duration.