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Systemic absorption of topical and subconjunctival gentamicin
The British Journal of Ophthalmology
|October 1, 1979
Summary
Ocular gentamicin therapy showed no systemic absorption with topical use but did with subconjunctival administration. This review discusses the safety of ocular gentamicin, considering different administration routes.
Area of Science:
- Ophthalmology
- Pharmacokinetics
- Infectious Diseases
Background:
- Gentamicin is an aminoglycoside antibiotic used for ocular infections.
- Ocular drug delivery presents challenges due to anatomical barriers.
- Systemic absorption can lead to adverse effects.
Purpose of the Study:
- To evaluate systemic absorption of ocular gentamicin.
- To compare absorption between topical and subconjunctival routes.
- To review the safety profile of ocular gentamicin therapy.
Main Methods:
- Ten patients received ocular gentamicin.
- Administration routes included topical and subconjunctival.
- Systemic absorption was monitored.
Main Results:
- No systemic absorption detected after topical ocular gentamicin.
- Systemic absorption was detected after subconjunctival gentamicin.
- The study highlights route-dependent systemic exposure.
Conclusions:
- Topical ocular gentamicin appears to have minimal systemic absorption.
- Subconjunctival gentamicin leads to detectable systemic levels.
- Safety considerations for ocular gentamicin depend on the administration route.